MRPL54

Across TCGA patient cohorts, MRPL54 mutation is significantly associated with the RNA expression of many other genes, with 152 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible MRPL54-associated genes across cancer lineages are REXO1L8P, NIPA2P4, and OR11N1P. Each is linked with MRPL54 in more than 2 cancer types. Because this analysis shows association rather than direction, both MRPL54-to-partner and partner-to-MRPL54 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REXO1L8P grouped by MRPL54-low versus MRPL54-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL54→partner) and Y-score (partner→MRPL54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	REXO1L8P →	+0.049	+7.142	<.001	<.001	3	3
SKCM	NIPA2P4 →	+0.023	+2.695	<.001	.003	3	2
SKCM	OR11N1P →	+0.059	+2.669	<.001	.007	3	2
UCEC	RNA5SP413 →	+1.647	+3.277	<.001	.009	3	2
UCEC	RNA5SP422 →	+1.389	+3.671	<.001	.003	3	2
COAD	MIR4774 →	+1.536	+5.516	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 152 associations by consensus.

REXO1L8P by MRPL54 expression — COAD

Explore this box plot interactively →