Across TCGA patient cohorts, MRPL53 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,168 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible MRPL53-associated GO terms across cancer lineages are Mitotic intra-S DNA damage checkpoint signaling, Mitochondrial translation, and Base-excision repair. Each is linked with MRPL53 in more than 27 cancer types. Because this analysis shows association rather than direction, both MRPL53-to-partner and partner-to-MRPL53 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL53→partner) and Y-score (partner→MRPL53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Mitotic intra-S DNA damage checkpoint signaling →	+0.053	+0.354	<.001	<.001	3	28
STAD	Mitochondrial translation →	+0.058	+0.398	<.001	<.001	3	28
STAD	Base-excision repair →	+0.049	+0.365	<.001	<.001	3	27
KIRC	Base-excision repair, gap-filling →	+0.055	+0.654	<.001	<.001	3	27
STAD	Mitotic recombination →	+0.042	+0.287	<.001	<.001	3	27
STAD	Mitochondrial gene expression →	+0.059	+0.418	<.001	<.001	3	27

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,168 associations by consensus.

Exploration

MRPL53 survival (RNA) · tumor vs normal (RNA) · all MRPL53 data types