Across TCGA patient cohorts, MRPL53 protein abundance is significantly associated with the RNA expression of many other genes, with 15,155 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MRPL53-associated genes across cancer lineages are CLEC1A, CERCAM, and NDN. Each is linked with MRPL53 in more than 6 cancer types. Because this analysis shows association rather than direction, both MRPL53-to-partner and partner-to-MRPL53 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL53→partner) and Y-score (partner→MRPL53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CLEC1A →	-0.601	-0.487	<.001	<.001	3	6
OV	CERCAM →	-0.960	-0.526	.004	<.001	2	7
COAD	NDN →	-0.767	-0.349	<.001	<.001	3	6
OV	ROR1 →	-0.787	-0.323	<.001	.003	3	6
BRCA	PHLDB2 →	-0.824	-0.401	<.001	<.001	3	6
OV	LRRC4C →	-0.818	-0.426	.003	.009	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,155 associations by consensus.

Exploration

MRPL53 survival (RNA) · tumor vs normal (RNA) · all MRPL53 data types