Across TCGA patient cohorts, MRPL53 mutation is significantly associated with the RNA expression of many other genes, with 47 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible MRPL53-associated genes across cancer lineages are XAGE1A, RNA5SP109, and KRTAP8-2P. Each is linked with MRPL53 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL53-to-partner and partner-to-MRPL53 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL53→partner) and Y-score (partner→MRPL53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	XAGE1A →	+0.241	+5.473	<.001	.005	3	2
BRCA	RNA5SP109 →	+0.331	+6.505	<.001	.001	3	2
LUSC	KRTAP8-2P →	+0.811	+5.792	<.001	.003	3	2
SKCM	WASHC3P1 →	+0.136	+4.884	<.001	.004	3	2
BRCA	MIR3118-3 →	+0.371	+7.471	<.001	.008	3	1
BRCA	MIR2115 →	+0.443	+5.203	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Exploration

MRPL53 survival (RNA) · tumor vs normal (RNA) · all MRPL53 data types