Across TCGA cell cohorts, MRPL53 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,051 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible MRPL53-associated GO terms across cancer lineages are 7-methylguanosine cap hypermethylation, Cell junction assembly, and Iron-sulfur cluster assembly. Each is linked with MRPL53 in more than 9 cancer types. Because this analysis shows association rather than direction, both MRPL53-to-partner and partner-to-MRPL53 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL53→partner) and Y-score (partner→MRPL53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	7-methylguanosine cap hypermethylation →	+0.087	+0.750	.001	.003	3	10
UPPER_AERODIGESTIVE_TRACT	Cell junction assembly →	-0.077	-0.849	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Iron-sulfur cluster assembly →	+0.097	+0.969	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Metallo-sulfur cluster assembly →	+0.097	+0.969	<.001	<.001	3	7
SKIN	Spliceosomal conformational changes to generate catalytic conformation →	+0.043	+0.461	.002	<.001	3	7
LUNG_SCLC	Regulation of lysosome size →	+0.097	+0.569	.002	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,051 associations by consensus.

Exploration

MRPL53 survival (RNA) · tumor vs normal (RNA) · all MRPL53 data types