MRPL52

Across TCGA pan-cancer cohorts, MRPL52 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MRPL52 data layer compared with 24 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher MRPL52 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MRPL52 expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

COAD, LUAD, and HNSC are the cancer types where MRPL52 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.922	.017	36	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	9	view →
HNSC	OS	Median	All	0.939	0.993	.020	6	view →
PDAC	DFS	Tertile	IV	0.752	0.205	.024	6	view →
CCRCC	DFS	Quartile	All	0.935	0.691	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MRPL52–COAD (DFS)

Open the COAD breakdown →