MRPL52

Across TCGA patient cohorts, MRPL52 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL52-associated genes across cancer lineages are MIR6133, TTTY8B, and MIR1298. Each is linked with MRPL52 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL52-to-partner and partner-to-MRPL52 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6133 grouped by MRPL52-low versus MRPL52-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL52→partner) and Y-score (partner→MRPL52) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6133 →	+0.479	+3.567	.001	.005	3	1
BRCA	TTTY8B →	+0.059	+8.055	<.001	.007	3	1
BRCA	MIR1298 →	+0.300	+7.731	<.001	.009	3	1
BRCA	MTCO3P30 →	+0.274	+8.055	<.001	.007	3	1
BRCA	LINC02729 →	+0.074	+7.731	<.001	.009	3	1
BLCA	RNA5-8SP7 →	+0.398	+7.640	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

MIR6133 by MRPL52 expression — UCEC

Explore this box plot interactively →