MRPL51

Across TCGA pan-cancer cohorts, MRPL51 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MRPL51 data layer compared with 29 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher MRPL51 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MRPL51 expression acts as an unfavorable survival marker.

CESC, STAD, and HNSC are the cancer types where MRPL51 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	All	0.167	0.798	<.001	30	view →
STAD	OS	Median	II,III,IV	0.175	0.677	.002	24	view →
HNSC	DFS	Median	All	0.209	0.710	.032	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MRPL51–CESC (OS)

Open the CESC breakdown →