MRPL51

Across TCGA pan-cancer cohorts, MRPL51 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MRPL51 data layer compared with 29 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher MRPL51 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MRPL51 expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

COAD, HNSC, and GBM are the cancer types where MRPL51 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	II,III,IV	1.000	0.889	.024	18	view →
HNSC	DFS	Median	IV	0.494	0.765	.016	15	view →
GBM	DFS	Median	All	0.666	0.805	.010	7	view →
LUAD	DFS	Tertile	II,III,IV	0.993	0.709	.037	3	view →
CCRCC	DFS	Tertile	II,III,IV	0.526	1.000	.040	1	view →
LSCC	DFS	Median	III,IV	0.882	1.000	.049	1	view →
PDAC	OS	Median	III,IV	0.618	0.886	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MRPL51–COAD (DFS)

Open the COAD breakdown →