MRPL50

Across TCGA pan-cancer cohorts, MRPL50 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MRPL50 data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher MRPL50 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MRPL50 expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

COAD, HNSC, and PDAC are the cancer types where MRPL50 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	1.000	0.911	.012	42	view →
HNSC	DFS	Median	IV	0.664	0.916	.008	19	view →
PDAC	OS	Tertile	IV	0.231	0.916	.024	6	view →
LUAD	DFS	Quartile	III,IV	0.768	0.245	.006	5	view →
LSCC	OS	Median	All	0.883	0.750	.027	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MRPL50–COAD (DFS)

Open the COAD breakdown →