MRPL50

Across TCGA patient cohorts, MRPL50 mutation is significantly associated with the RNA expression of many other genes, with 672 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL50-associated genes across cancer lineages are SNRPGP8, RPS3AP17, and MIR98. Each is linked with MRPL50 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL50-to-partner and partner-to-MRPL50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNRPGP8 grouped by MRPL50-low versus MRPL50-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL50→partner) and Y-score (partner→MRPL50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNRPGP8 →	+0.139	+3.352	<.001	.004	3	2
UCEC	RPS3AP17 →	+0.080	+2.677	.007	.007	3	2
UCEC	MIR98 →	+0.408	+2.801	<.001	.005	3	1
UCEC	STMN1P1 →	+0.437	+3.330	.003	.009	3	1
UCEC	TADA2A →	+0.522	+3.459	.002	.005	3	1
UCEC	PIGW →	+0.803	+3.470	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 672 associations by consensus.

SNRPGP8 by MRPL50 expression — UCEC

Explore this box plot interactively →