MRPL50

Across TCGA patient cohorts, MRPL50 mutation is significantly associated with the immune_cell of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL50-associated genes across cancer lineages are aDC, CD8+ naive T-cells, and Erythrocytes. Each is linked with MRPL50 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL50-to-partner and partner-to-MRPL50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, aDC grouped by MRPL50-low versus MRPL50-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL50→partner) and Y-score (partner→MRPL50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	aDC →	+0.081	+3.008	.029	.019	3	1
UCEC	CD8+ naive T-cells →	+0.028	+2.839	.040	.034	3	1
UCEC	Erythrocytes →	+0.030	+2.879	.017	.033	3	1
UCEC	mv Endothelial cells →	-0.028	-2.311	.017	.036	3	1
UCEC	Th2 cells →	+0.277	+3.177	.002	.010	3	1
UCEC	Endothelial cells →	-0.050	-3.416	.008	.005	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

aDC by MRPL50 expression — UCEC

Explore this box plot interactively →