MRPL48

Across TCGA pan-cancer cohorts, MRPL48 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MRPL48 data layer compared with 23 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher MRPL48 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MRPL48 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

CCRCC, GBM, and LUAD are the cancer types where MRPL48 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.709	1.000	.010	5	view →
GBM	OS	Median	All	0.640	0.391	.018	3	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	3	view →
HNSC	DFS	Median	IV	0.688	0.881	.035	2	view →
PDAC	DFS	Tertile	All	0.805	0.893	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MRPL48–CCRCC (DFS)

Open the CCRCC breakdown →