MRPL47

Across TCGA pan-cancer cohorts, MRPL47 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of MRPL47’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where MRPL47 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types MRPL47 is over-expressed in tumor, although a few such as CCRCC and PDAC show the opposite, repressed pattern.

CCRCC, LUAD, and COAD are the cancer types where MRPL47 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MRPL47 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	All	−0.677	<.001	11	view →
LUAD	Female	II,III,IV	+0.871	<.001	9	view →
COAD	Male	III,IV	+0.473	<.001	9	view →
LSCC	Male	II,III,IV	+0.888	<.001	8	view →
PDAC	All	All	−0.272	.002	4	view →
OV	All	All	+0.402	.016	2	view →
HNSC	All	III,IV	+0.121	.023	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

MRPL47–CCRCC

Open the CCRCC breakdown →