MRPL47

Across TCGA patient cohorts, MRPL47 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL47-associated genes across cancer lineages are FASN, FoxM1, and ACC1. Each is linked with MRPL47 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL47-to-partner and partner-to-MRPL47 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by MRPL47-low versus MRPL47-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL47→partner) and Y-score (partner→MRPL47) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.681	+2.000	<.001	.032	3	1
UCEC	FoxM1 →	+0.311	+3.807	.007	<.001	3	1
UCEC	ACC1 →	+0.404	+2.820	.013	.035	3	1
UCEC	p62 Lck ligand →	+0.361	+2.179	.013	.034	3	1
UCEC	PCNA →	+0.192	+2.000	.048	.032	3	1
UCEC	SCD →	+0.133	+2.013	.007	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

FASN by MRPL47 expression — UCEC

Explore this box plot interactively →