MRPL46

Across TCGA pan-cancer cohorts, MRPL46 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated MRPL46 data layer compared with 27 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher MRPL46 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated MRPL46 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KIRP and UCEC are the cancer types where MRPL46 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.037	0.920	<.001	24	view →
UCEC	DFS	Median	II,III,IV	1.000	0.445	.045	4	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

MRPL46–KIRP (DFS)

Open the KIRP breakdown →