MRPL46

Across TCGA patient cohorts, MRPL46 mutation is significantly associated with the RNA expression of many other genes, with 480 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL46-associated genes across cancer lineages are MCHR2, ZNF479, and MRPS18BP1. Each is linked with MRPL46 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL46-to-partner and partner-to-MRPL46 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MCHR2 grouped by MRPL46-low versus MRPL46-high in SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL46→partner) and Y-score (partner→MRPL46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	MCHR2 →	+0.351	+4.847	<.001	.009	3	1
SCLC	ZNF479 →	+0.075	+5.189	.005	.006	3	1
BRCA	MRPS18BP1 →	+0.238	+6.112	<.001	.002	3	1
UCEC	FBXO7 →	+0.455	+3.606	.007	.001	3	1
UCEC	L3MBTL2 →	+0.397	+3.500	.008	.002	3	1
UCEC	ACO2 →	+0.887	+3.475	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 480 associations by consensus.

MCHR2 by MRPL46 expression — SCLC

Explore this box plot interactively →