MRPL46

Across TCGA cell cohorts, MRPL46 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,712 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible MRPL46-associated GO terms across cancer lineages are Mitochondrial translation, rRNA pseudouridine synthesis, and Resolution of DNA recombination intermediates. Each is linked with MRPL46 in more than 14 cancer types. Because this analysis shows association rather than direction, both MRPL46-to-partner and partner-to-MRPL46 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrial translation grouped by MRPL46-low versus MRPL46-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL46→partner) and Y-score (partner→MRPL46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Mitochondrial translation →	+0.117	+0.959	<.001	<.001	3	15
BONE	rRNA pseudouridine synthesis →	+0.118	+0.585	.001	<.001	3	14
BONE	Resolution of DNA recombination intermediates →	+0.143	+0.547	<.001	<.001	3	13
BONE	DNA replication checkpoint signaling →	+0.154	+0.390	.008	.009	2	14
PANCREAS	Mitotic DNA replication checkpoint signaling →	+0.142	+0.774	.001	<.001	3	13
BLOOD_Lymphoma	Mitochondrial ribosome assembly →	+0.097	+0.651	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,712 associations by consensus.

Mitochondrial translation by MRPL46 expression — BLOOD_Myeloma

Explore this box plot interactively →