MRPL46

Across TCGA cell cohorts, MRPL46 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MRPL46-associated genes across cancer lineages are PLPPR1, GRM1, and FAM153B. Each is linked with MRPL46 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL46-to-partner and partner-to-MRPL46 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLPPR1 grouped by MRPL46-low versus MRPL46-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL46→partner) and Y-score (partner→MRPL46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PLPPR1 →	+0.450	+3.285	<.001	.008	3	1
LARGE_INTESTINE	GRM1 →	+0.034	+3.750	<.001	.007	3	1
LARGE_INTESTINE	FAM153B →	+0.424	+3.011	<.001	.003	3	1
LARGE_INTESTINE	LRRC3C →	+0.224	+3.144	.001	.001	3	1
LARGE_INTESTINE	GAS2L2 →	+0.095	+3.070	<.001	.002	3	1
LARGE_INTESTINE	KCNN2 →	+0.628	+3.215	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

PLPPR1 by MRPL46 expression — LARGE_INTESTINE

Explore this box plot interactively →