MRPL45

Across TCGA patient cohorts, MRPL45 mutation is significantly associated with the RNA expression of many other genes, with 1,227 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL45-associated genes across cancer lineages are OR5K3, CCDC153, and BPY2DP. Each is linked with MRPL45 in more than 2 cancer types. Because this analysis shows association rather than direction, both MRPL45-to-partner and partner-to-MRPL45 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5K3 grouped by MRPL45-low versus MRPL45-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL45→partner) and Y-score (partner→MRPL45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR5K3 →	+0.013	+5.228	<.001	.001	3	3
UCEC	CCDC153 →	-0.969	-3.700	.002	.001	3	2
COAD	BPY2DP →	+0.319	+7.409	<.001	<.001	3	2
LUAD	RNA5SP393 →	+0.365	+4.194	.005	.009	3	2
LUAD	RNU4-27P →	+0.224	+5.197	<.001	.003	3	2
BLCA	RNU4-88P →	+0.348	+7.640	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,227 associations by consensus.

OR5K3 by MRPL45 expression — SKCM

Explore this box plot interactively →