MRPL43

Across TCGA pan-cancer cohorts, MRPL43 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MRPL43 data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher MRPL43 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MRPL43 expression acts as an unfavorable survival marker, although some lineages such as COAD and LSCC show a favorable association.

COAD, LSCC, and LUAD are the cancer types where MRPL43 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	1.000	0.912	.013	42	view →
LSCC	DFS	Tertile	II,III,IV	0.896	0.547	.016	6	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	4	view →
HNSC	OS	Median	IV	0.774	0.889	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MRPL43–COAD (DFS)

Open the COAD breakdown →