MRPL43

Across TCGA patient cohorts, MRPL43 mutation is significantly associated with the RNA expression of many other genes, with 743 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL43-associated genes across cancer lineages are RN7SL314P, RNA5SP492, and TCERG1P1. Each is linked with MRPL43 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL43-to-partner and partner-to-MRPL43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL314P grouped by MRPL43-low versus MRPL43-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL43→partner) and Y-score (partner→MRPL43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SL314P →	+0.103	+5.039	.003	.003	3	2
SKCM	RNA5SP492 →	+0.329	+4.622	<.001	.001	3	2
SKCM	TCERG1P1 →	+0.067	+5.021	<.001	<.001	3	2
UCEC	RPS29P21 →	+0.434	+2.541	.002	.001	3	2
BRCA	OR7E125P →	+0.044	+9.057	<.001	.003	3	1
BRCA	MIR208A →	+0.368	+8.471	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 743 associations by consensus.

RN7SL314P by MRPL43 expression — SKCM

Explore this box plot interactively →