MRPL43

Across TCGA patient cohorts, MRPL43 mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL43-associated genes across cancer lineages are Class-switched memory B-cells, Macrophages M2, and MEP. Each is linked with MRPL43 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL43-to-partner and partner-to-MRPL43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Class-switched memory B-cells grouped by MRPL43-low versus MRPL43-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL43→partner) and Y-score (partner→MRPL43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Class-switched memory B-cells →	-0.056	-3.584	.041	.003	3	1
UCEC	Macrophages M2 →	+0.010	+3.024	.039	.019	2	1
UCEC	MEP →	+0.028	+2.470	.037	.011	1	1
UCEC	Mesangial cells →	-0.067	-3.574	<.001	.003	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Class-switched memory B-cells by MRPL43 expression — UCEC

Explore this box plot interactively →