MRPL43

Across TCGA cell cohorts, MRPL43 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,008 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible MRPL43-associated GO terms across cancer lineages are Base-excision repair, gap-filling, Spindle elongation, and Ornithine metabolic process. Each is linked with MRPL43 in more than 10 cancer types. Because this analysis shows association rather than direction, both MRPL43-to-partner and partner-to-MRPL43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Base-excision repair, gap-filling grouped by MRPL43-low versus MRPL43-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL43→partner) and Y-score (partner→MRPL43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Base-excision repair, gap-filling →	+0.135	+0.754	<.001	<.001	3	10
LUNG_NSCLC_LUSC	Spindle elongation →	+0.210	+0.453	.006	.009	2	11
LUNG_SCLC	Ornithine metabolic process →	+0.124	+0.482	<.001	.006	2	10
LUNG_SCLC	IMP catabolic process →	+0.159	+0.660	<.001	<.001	3	9
BLOOD_Myeloma	Protein localization to endosome →	+0.112	+0.902	.001	<.001	3	9
SOFT_TISSUE	Protein to membrane docking →	+0.067	+0.430	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,008 associations by consensus.

Base-excision repair, gap-filling by MRPL43 expression — BREAST

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