MRPL40P1

Across TCGA pan-cancer cohorts, MRPL40P1 RNA differs between tumor and matched normal tissue in 18 of 18 cancer types tested, making tumor–normal expression one of MRPL40P1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MRPL40P1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MRPL40P1 is over-expressed in tumor, although a few such as PAAD and KICH show the opposite, repressed pattern.

KIRC, THCA, and HNSC are the cancer types where MRPL40P1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MRPL40P1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.253	<.001	9	view →
THCA	Male	All	+0.811	<.001	8	view →
HNSC	Male	All	+0.264	<.001	8	view →
COAD	All	II,III,IV	+0.216	<.001	8	view →
LUAD	All	All	+0.378	<.001	7	view →
LIHC	All	II,III,IV	+0.262	<.001	7	view →
UCEC	All	All	+0.634	<.001	6	view →
BRCA	All	III,IV	+0.630	<.001	6	view →
BLCA	All	All	+0.446	<.001	6	view →
STAD	All	II,III,IV	+0.298	<.001	6	view →
KIRP	All	All	+0.146	.018	6	view →
LUSC	All	All	+0.338	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 18 lineages.

MRPL40P1–KIRC

Open the KIRC breakdown →