Across TCGA patient cohorts, MRPL40 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL40-associated genes across cancer lineages are Ku80, p62 Lck ligand, and CDK1_pY15. Each is linked with MRPL40 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL40-to-partner and partner-to-MRPL40 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL40→partner) and Y-score (partner→MRPL40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.279	+3.013	.041	.019	2	1
UCEC	p62 Lck ligand →	+0.432	+3.000	.021	.037	2	1
UCEC	CDK1_pY15 →	+0.299	+2.829	.012	.035	2	1
UCEC	eIF4G →	+0.484	+3.000	.006	.037	1	1
UCEC	Cyclin-B1 →	+0.897	+3.000	.005	.037	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

MRPL40 survival (RNA) · tumor vs normal (RNA) · all MRPL40 data types