MRPL4

Across TCGA patient cohorts, MRPL4 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL4-associated genes across cancer lineages are mTOR, p62 Lck ligand, and VHL. Each is linked with MRPL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL4-to-partner and partner-to-MRPL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR grouped by MRPL4-low versus MRPL4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL4→partner) and Y-score (partner→MRPL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR →	-0.242	-2.321	.001	.034	3	1
UCEC	p62 Lck ligand →	+0.345	+3.179	.023	.010	3	1
UCEC	VHL →	-0.962	-2.321	.002	.034	3	1
UCEC	MEK1 →	+0.481	+3.321	.004	.010	2	1
UCEC	Rb →	-0.193	-3.150	.020	.019	2	1
UCEC	Caspase-8 →	-0.269	-3.321	.022	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

mTOR by MRPL4 expression — UCEC

Explore this box plot interactively →