MRPL4

Across TCGA cell cohorts, MRPL4 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MRPL4-associated genes across cancer lineages are RNASE8, OR51D1, and CROCC2. Each is linked with MRPL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL4-to-partner and partner-to-MRPL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNASE8 grouped by MRPL4-low versus MRPL4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL4→partner) and Y-score (partner→MRPL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RNASE8 →	+0.051	+3.930	<.001	.003	3	1
LARGE_INTESTINE	OR51D1 →	+0.009	+4.217	<.001	.001	3	1
LARGE_INTESTINE	CROCC2 →	+0.182	+3.793	<.001	.007	3	1
OVARY	PFN3 →	+0.070	+4.450	<.001	.004	3	1
OVARY	OR8D2 →	+0.017	+4.807	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

RNASE8 by MRPL4 expression — LARGE_INTESTINE

Explore this box plot interactively →