Across TCGA patient cohorts, MRPL38 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL38-associated genes across cancer lineages are EGFR_pY1068, S6_pS240_S244, and STAT3_pY705. Each is linked with MRPL38 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL38-to-partner and partner-to-MRPL38 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL38→partner) and Y-score (partner→MRPL38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.260	-2.459	.032	.020	3	1
UCEC	S6_pS240_S244 →	+0.435	+2.459	.026	.020	3	1
UCEC	STAT3_pY705 →	-0.267	-2.459	.035	.020	3	1
UCEC	Caspase-7-cleavedD198 →	+0.786	+2.189	.006	.034	3	1
UCEC	Cyclin-B1 →	+0.538	+2.459	.047	.020	3	1
UCEC	Caspase-8 →	-0.277	-3.321	.022	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

MRPL38 survival (RNA) · tumor vs normal (RNA) · all MRPL38 data types