MRPL36

Across TCGA patient cohorts, MRPL36 mutation is significantly associated with the RNA expression of many other genes, with 744 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL36-associated genes across cancer lineages are CRYBB2P1, APOBEC3H, and ACOD1. Each is linked with MRPL36 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL36-to-partner and partner-to-MRPL36 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRYBB2P1 grouped by MRPL36-low versus MRPL36-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL36→partner) and Y-score (partner→MRPL36) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CRYBB2P1 →	+0.599	+3.480	.003	.002	3	1
UCEC	APOBEC3H →	+0.623	+3.502	.005	.002	3	1
UCEC	ACOD1 →	+0.178	+3.037	<.001	.002	3	1
UCEC	MON1B →	+0.533	+3.513	.003	.002	3	1
UCEC	AIMP2 →	+0.764	+3.483	.001	.002	3	1
UCEC	FSCN3 →	+0.150	+3.439	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 744 associations by consensus.

CRYBB2P1 by MRPL36 expression — UCEC

Explore this box plot interactively →