MRPL35

Across TCGA patient cohorts, MRPL35 mutation is significantly associated with the RNA expression of many other genes, with 1,091 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL35-associated genes across cancer lineages are OR2AI1P, RN7SKP286, and POLR2DP1. Each is linked with MRPL35 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL35-to-partner and partner-to-MRPL35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2AI1P grouped by MRPL35-low versus MRPL35-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL35→partner) and Y-score (partner→MRPL35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	OR2AI1P →	+0.047	+4.669	<.001	.007	3	2
BLCA	RN7SKP286 →	+0.143	+7.640	<.001	.009	3	2
CESC	POLR2DP1 →	+0.091	+4.669	<.001	.007	3	2
BLCA	RN7SKP236 →	+0.384	+7.640	<.001	.009	3	2
BLCA	RN7SL422P →	+0.164	+7.640	<.001	.009	3	2
BLCA	MIR654 →	+0.433	+7.640	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,091 associations by consensus.

OR2AI1P by MRPL35 expression — CESC

Explore this box plot interactively →