MRPL35

Across TCGA patient cohorts, MRPL35 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL35-associated genes across cancer lineages are EGFR_pY1068, MEK1, and TSC1. Each is linked with MRPL35 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL35-to-partner and partner-to-MRPL35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by MRPL35-low versus MRPL35-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL35→partner) and Y-score (partner→MRPL35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.284	-2.459	.019	.020	3	2
UCEC	MEK1 →	+0.368	+3.000	.037	.036	3	2
UCEC	TSC1 →	-0.253	-2.459	.002	.020	3	2
UCEC	ERK2 →	+0.298	+3.584	.001	.002	2	2
UCEC	Annexin-1 →	+0.664	+2.827	.009	.035	3	1
UCEC	TIGAR →	+0.162	+2.486	.028	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

EGFR_pY1068 by MRPL35 expression — UCEC

Explore this box plot interactively →