MRPL33

Across TCGA pan-cancer cohorts, MRPL33 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of MRPL33’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MRPL33 RNA is repressed in tumor relative to normal tissue. In most cancer types MRPL33 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and LIHC are the cancer types where MRPL33 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MRPL33 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.018	<.001	12	view →
KICH	Female	II,III,IV	−2.424	<.001	10	view →
LIHC	Male	II,III,IV	+1.330	<.001	9	view →
CHOL	All	All	+1.664	<.001	3	view →
LUAD	All	All	+0.278	.003	3	view →
ESCA	Female	All	+0.760	.015	2	view →
KIRP	All	All	−0.382	.029	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

MRPL33–KIRC

Open the KIRC breakdown →