MRPL3

Across TCGA patient cohorts, MRPL3 mutation is significantly associated with the RNA expression of many other genes, with 2,063 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL3-associated genes across cancer lineages are RNA5SP405, IGHD2-2, and AKR1B1P3. Each is linked with MRPL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL3-to-partner and partner-to-MRPL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP405 grouped by MRPL3-low versus MRPL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL3→partner) and Y-score (partner→MRPL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP405 →	+0.288	+3.167	<.001	.005	3	2
UCEC	IGHD2-2 →	+1.151	+1.802	.002	.005	3	2
UCEC	AKR1B1P3 →	+0.255	+1.949	<.001	.009	3	2
BRCA	RNA5SP262 →	+0.314	+8.055	.001	.007	3	1
BRCA	ENPP7P13 →	+0.119	+8.055	<.001	.007	3	1
UCEC	LIN7C →	+0.553	+2.708	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,063 associations by consensus.

RNA5SP405 by MRPL3 expression — UCEC

Explore this box plot interactively →