MRPL3

Across TCGA patient cohorts, MRPL3 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL3-associated genes across cancer lineages are Tuberin_pT1462, A-Raf_pS299, and GSK-3a-b_pS21_S9. Each is linked with MRPL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL3-to-partner and partner-to-MRPL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tuberin_pT1462 grouped by MRPL3-low versus MRPL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL3→partner) and Y-score (partner→MRPL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Tuberin_pT1462 →	+0.346	+2.700	<.001	.006	3	2
UCEC	A-Raf_pS299 →	-0.127	-2.000	.018	.032	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.418	+2.179	.029	.034	3	1
UCEC	INPP4B →	-0.321	-3.169	.027	.019	3	1
UCEC	JNK2 →	+0.218	+2.331	.015	.019	3	1
UCEC	PRAS40_pT246 →	+0.187	+3.169	.015	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Tuberin_pT1462 by MRPL3 expression — UCEC

Explore this box plot interactively →