MRPL28

Across TCGA patient cohorts, MRPL28 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL28-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and A-Raf_pS299. Each is linked with MRPL28 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL28-to-partner and partner-to-MRPL28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by MRPL28-low versus MRPL28-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL28→partner) and Y-score (partner→MRPL28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.298	-2.584	.010	.011	3	1
UCEC	eIF4E →	+0.199	+2.820	.043	.035	3	1
UCEC	A-Raf_pS299 →	-0.161	-3.000	.003	.036	3	1
UCEC	ERK2 →	+0.182	+2.584	.042	.011	3	1
UCEC	FOXO3a_pS318_S321 →	-0.172	-2.312	.003	.034	3	1
UCEC	MSH6 →	-0.410	-2.990	.007	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

EGFR_pY1068 by MRPL28 expression — UCEC

Explore this box plot interactively →