MRPL27

Across TCGA pan-cancer cohorts, MRPL27 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MRPL27 data layer compared with 24 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher MRPL27 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MRPL27 expression acts as an unfavorable survival marker, although some lineages such as COAD and LSCC show a favorable association.

COAD, HNSC, and PDAC are the cancer types where MRPL27 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	1.000	0.912	.013	36	view →
HNSC	DFS	Quartile	IV	0.737	0.961	.011	10	view →
PDAC	OS	Tertile	All	0.398	0.627	.019	6	view →
CCRCC	OS	Median	III,IV	0.542	0.802	.019	5	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	5	view →
LSCC	DFS	Quartile	II,III,IV	0.899	0.582	.036	5	view →
GBM	OS	Tertile	All	0.640	0.368	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MRPL27–COAD (DFS)

Open the COAD breakdown →