MRPL27

Across TCGA patient cohorts, MRPL27 mutation is significantly associated with the RNA expression of many other genes, with 200 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL27-associated genes across cancer lineages are LINC01022, RN7SL337P, and RNA5SP136. Each is linked with MRPL27 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL27-to-partner and partner-to-MRPL27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01022 grouped by MRPL27-low versus MRPL27-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL27→partner) and Y-score (partner→MRPL27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC01022 →	+0.184	+2.599	<.001	.009	3	2
BLCA	RN7SL337P →	+0.346	+5.038	<.001	.009	3	2
UCEC	RNA5SP136 →	+0.313	+3.299	<.001	.001	3	2
UCEC	RNVU1-23 →	+0.541	+2.221	.001	.009	3	2
UCEC	LINC02084 →	+0.744	+3.202	<.001	.009	3	1
UCEC	MIR6085 →	+0.499	+2.221	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 200 associations by consensus.

LINC01022 by MRPL27 expression — UCEC

Explore this box plot interactively →