MRPL27

Across TCGA cell cohorts, MRPL27 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,267 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible MRPL27-associated GO terms across cancer lineages are [2Fe-2S] cluster assembly, Quinone metabolic process, and DNA replication checkpoint signaling. Each is linked with MRPL27 in more than 12 cancer types. Because this analysis shows association rather than direction, both MRPL27-to-partner and partner-to-MRPL27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, [2Fe-2S] cluster assembly grouped by MRPL27-low versus MRPL27-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL27→partner) and Y-score (partner→MRPL27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	[2Fe-2S] cluster assembly →	+0.099	+0.560	.001	.004	3	13
BLOOD_Leukemia	Quinone metabolic process →	+0.072	+0.543	<.001	<.001	3	11
PANCREAS	DNA replication checkpoint signaling →	+0.137	+0.857	.001	.001	3	11
BLOOD_Myeloma	Iron-sulfur cluster assembly →	+0.089	+0.786	.003	.003	3	10
BLOOD_Myeloma	Metallo-sulfur cluster assembly →	+0.089	+0.786	.003	.003	3	10
KIDNEY	Replication fork arrest →	+0.123	+0.541	.004	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,267 associations by consensus.

[2Fe-2S] cluster assembly by MRPL27 expression — URINARY_TRACT

Explore this box plot interactively →