MRPL22

Across TCGA patient cohorts, MRPL22 mutation is significantly associated with the immune_cell of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL22-associated genes across cancer lineages are CD8+ Tem and Macrophages M2. Each is linked with MRPL22 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL22-to-partner and partner-to-MRPL22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ Tem grouped by MRPL22-low versus MRPL22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL22→partner) and Y-score (partner→MRPL22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD8+ Tem →	+0.005	+5.258	<.001	.029	3	1
UCEC	Macrophages M2 →	+0.017	+2.925	.008	.031	1	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

CD8+ Tem by MRPL22 expression — UCEC

Explore this box plot interactively →