MRPL22

Across TCGA cell cohorts, MRPL22 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,497 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MRPL22-associated GO terms across cancer lineages are Mitochondrial translation, Positive regulation of G2/MI transition of meiotic cell cycle, and Mitochondrial gene expression. Each is linked with MRPL22 in more than 12 cancer types. Because this analysis shows association rather than direction, both MRPL22-to-partner and partner-to-MRPL22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrial translation grouped by MRPL22-low versus MRPL22-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL22→partner) and Y-score (partner→MRPL22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Mitochondrial translation →	+0.109	+1.037	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Positive regulation of G2/MI transition of meiotic cell cycle →	+0.120	+0.667	.007	.007	2	12
BLOOD_Myeloma	Mitochondrial gene expression →	+0.073	+0.839	.001	.001	3	11
UPPER_AERODIGESTIVE_TRACT	Protein import into mitochondrial intermembrane space →	+0.132	+0.799	<.001	.001	3	11
BLOOD_Lymphoma	Regulation of mitochondrial gene expression →	+0.039	+0.517	.008	.001	3	11
BREAST	Mitochondrial respiratory chain complex assembly →	+0.075	+0.740	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,497 associations by consensus.

Mitochondrial translation by MRPL22 expression — BLOOD_Myeloma

Explore this box plot interactively →