MRPL22

Across TCGA cell cohorts, MRPL22 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MRPL22-associated genes across cancer lineages are S100G, OR2T8, and TFDP3. Each is linked with MRPL22 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL22-to-partner and partner-to-MRPL22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S100G grouped by MRPL22-low versus MRPL22-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL22→partner) and Y-score (partner→MRPL22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	S100G →	+1.365	+3.688	<.001	.002	3	1
LARGE_INTESTINE	OR2T8 →	+0.215	+3.693	<.001	.005	3	1
LARGE_INTESTINE	TFDP3 →	+0.020	+3.196	.001	.007	3	1
LARGE_INTESTINE	TAFA1 →	+0.274	+3.688	<.001	.002	3	1
LARGE_INTESTINE	NEXMIF →	+0.283	+3.196	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

S100G by MRPL22 expression — LARGE_INTESTINE

Explore this box plot interactively →