MRPL22

Across TCGA cell cohorts, MRPL22 mutation is significantly associated with the mutation status of many other genes, with 2,348 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MRPL22-associated genes across cancer lineages are MAP7D3, TSHR, and EOMES. Each is linked with MRPL22 in more than 2 cancer types. Because this analysis shows association rather than direction, both MRPL22-to-partner and partner-to-MRPL22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAP7D3 grouped by MRPL22-low versus MRPL22-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL22→partner) and Y-score (partner→MRPL22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MAP7D3 →	+4.736	+5.560	.003	.003	1	3
BLOOD_Leukemia	TSHR →	+4.321	+5.285	.005	.005	1	3
OVARY	EOMES →	+4.415	+4.977	.007	.007	1	3
LARGE_INTESTINE	FNDC3B →	+2.781	+4.504	<.001	<.001	1	3
LARGE_INTESTINE	ZNF831 →	+2.321	+4.129	.001	.001	1	3
LARGE_INTESTINE	MYH11 →	+2.321	+4.129	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,348 associations by consensus.

MAP7D3 by MRPL22 expression — BLOOD_Leukemia

Explore this box plot interactively →