Across TCGA patient cohorts, MRPL21 protein abundance is significantly associated with the RNA expression of many other genes, with 14,195 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MRPL21-associated genes across cancer lineages are IGSF6, ZEB2, and GLIPR2. Each is linked with MRPL21 in more than 5 cancer types. Because this analysis shows association rather than direction, both MRPL21-to-partner and partner-to-MRPL21 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL21→partner) and Y-score (partner→MRPL21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	IGSF6 →	-0.690	-0.319	<.001	<.001	3	6
COAD	ZEB2 →	-0.730	-0.327	<.001	<.001	3	6
BRCA	GLIPR2 →	-0.892	-0.339	<.001	<.001	3	6
COAD	CD226 →	-0.613	-0.360	<.001	<.001	3	6
OV	PNMA2 →	-1.179	-0.277	.001	.007	3	6
BRCA	RHOJ →	-1.008	-0.455	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,195 associations by consensus.

Exploration

MRPL21 survival (RNA) · tumor vs normal (RNA) · all MRPL21 data types