Across TCGA patient cohorts, MRPL21 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL21-associated genes across cancer lineages are PAI-1, Fibronectin, and Gab2. Each is linked with MRPL21 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL21-to-partner and partner-to-MRPL21 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL21→partner) and Y-score (partner→MRPL21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PAI-1 →	+0.635	+3.000	.001	.037	3	2
UCEC	Fibronectin →	+0.425	+2.817	.026	.036	3	1
UCEC	Gab2 →	+0.443	+3.000	.031	.037	3	1
UCEC	PDCD4 →	-0.700	-3.000	.010	.037	3	1
UCEC	EGFR_pY1173 →	+0.106	+3.026	.021	.019	2	1
UCEC	4E-BP1_pT37_T46 →	-0.506	-3.000	.019	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

MRPL21 survival (RNA) · tumor vs normal (RNA) · all MRPL21 data types