MRPL20

Across TCGA pan-cancer cohorts, MRPL20 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated MRPL20 data layer compared with 4 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher MRPL20 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MRPL20 expression acts as an unfavorable survival marker, although some lineages such as OV and KIRC show a favorable association.

KICH, UCEC, and LGG are the cancer types where MRPL20 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	III,IV	0.292	1.000	<.001	97	view →
UCEC	DFS	Quartile	IV	0.212	0.785	<.001	52	view →
LGG	DFS	Median	All	0.607	0.871	<.001	51	view →
ACC	OS	Median	IV	0.287	0.799	.006	50	view →
HNSC	DFS	Quartile	All	0.616	0.770	.002	45	view →
OV	DFS	Tertile	IV	0.650	0.323	.001	24	view →
KIRC	DFS	Tertile	All	0.723	0.440	.002	16	view →
DLBC	DFS	Median	III,IV	0.140	0.917	.010	16	view →
CHOL	DFS	Tertile	II,III,IV	0.725	0.152	.010	12	view →
MESO	DFS	Quartile	All	0.515	0.280	.035	12	view →
COAD	OS	Tertile	All	0.655	0.383	.005	12	view →
UCS	OS	Median	IV	0.224	0.732	.018	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

MRPL20–KICH (DFS)

Open the KICH breakdown →