MRPL20-DT

Across TCGA pan-cancer cohorts, MRPL20-DT RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated MRPL20-DT data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MRPL20-DT RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MRPL20-DT expression acts as an unfavorable survival marker, although some lineages such as SKCM and PAAD show a favorable association.

KIRC, ACC, and UCEC are the cancer types where MRPL20-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.481	0.727	<.001	160	view →
ACC	DFS	Median	All	0.279	0.617	<.001	100	view →
UCEC	DFS	Median	All	0.790	0.880	<.001	94	view →
LGG	DFS	Median	All	0.649	0.817	<.001	43	view →
SKCM	DFS	Median	IV	0.790	0.135	.003	30	view →
BRCA	DFS	Median	II,III,IV	0.864	0.912	.006	25	view →
PAAD	OS	Quartile	All	0.474	0.219	.002	20	view →
READ	OS	Median	II,III,IV	0.851	0.294	.004	20	view →
COAD	OS	Tertile	III,IV	0.565	0.865	.012	18	view →
PRAD	DFS	Median	All	0.827	0.935	<.001	18	view →
STAD	OS	Median	All	0.742	0.628	.008	17	view →
KIRP	DFS	Quartile	All	0.799	0.944	.008	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

MRPL20-DT–KIRC (DFS)

Open the KIRC breakdown →