MRPL18

Across TCGA pan-cancer cohorts, MRPL18 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of MRPL18’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where MRPL18 RNA is repressed in tumor relative to normal tissue. In most cancer types MRPL18 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KICH, HNSC, and COAD are the cancer types where MRPL18 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MRPL18 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.457	<.001	9	view →
HNSC	Male	IV	+0.983	<.001	9	view →
COAD	Female	II,III,IV	+0.599	<.001	9	view →
LIHC	Male	All	+0.773	<.001	8	view →
BLCA	All	All	+0.406	.002	8	view →
LUSC	Female	All	+0.745	<.001	7	view →
STAD	All	II,III,IV	+0.610	<.001	7	view →
KIRP	All	II,III,IV	+0.462	<.001	7	view →
LUAD	All	All	+0.335	<.001	7	view →
BRCA	All	II,III,IV	+0.328	<.001	6	view →
KIRC	All	All	+0.202	.001	5	view →
CHOL	All	All	+1.294	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

MRPL18–KICH

Open the KICH breakdown →