MRPL17

Across TCGA patient cohorts, MRPL17 mutation is significantly associated with the RNA expression of many other genes, with 74 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible MRPL17-associated genes across cancer lineages are RNU6-152P, RNA5SP84, and RNU7-176P. Each is linked with MRPL17 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL17-to-partner and partner-to-MRPL17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-152P grouped by MRPL17-low versus MRPL17-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL17→partner) and Y-score (partner→MRPL17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-152P →	+0.240	+5.147	.002	.003	3	2
UCEC	RNA5SP84 →	+0.584	+5.146	<.001	.001	3	2
COAD	RNU7-176P →	+0.537	+7.741	<.001	.009	3	1
LUAD	MIR383 →	+0.306	+7.930	<.001	.008	3	1
LUAD	TSPY4 →	+0.014	+7.930	.001	.008	3	1
LUAD	MIR6078 →	+0.233	+7.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

RNU6-152P by MRPL17 expression — BLCA

Explore this box plot interactively →