MRPL17

Across TCGA cell cohorts, MRPL17 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,720 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible MRPL17-associated GO terms across cancer lineages are rDNA heterochromatin formation, Protein K6-linked ubiquitination, and [4Fe-4S] cluster assembly. Each is linked with MRPL17 in more than 7 cancer types. Because this analysis shows association rather than direction, both MRPL17-to-partner and partner-to-MRPL17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, rDNA heterochromatin formation grouped by MRPL17-low versus MRPL17-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL17→partner) and Y-score (partner→MRPL17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	rDNA heterochromatin formation →	+0.091	+0.894	.005	.004	3	8
STOMACH	Protein K6-linked ubiquitination →	+0.093	+0.715	.002	<.001	3	8
URINARY_TRACT	[4Fe-4S] cluster assembly →	+0.124	+0.947	.002	<.001	3	7
URINARY_TRACT	Mitochondrial protein catabolic process →	+0.227	+1.050	<.001	<.001	3	7
BONE	Inner mitochondrial membrane organization →	+0.080	+0.559	.002	.005	3	7
URINARY_TRACT	GDP-mannose biosynthetic process →	+0.149	+0.854	.002	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,720 associations by consensus.

rDNA heterochromatin formation by MRPL17 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →